Evolution of a TRIM5-CypA Splice Isoform in Old World Monkeys

Evolution of a TRIM5-CypA Splice Isoform in Old World Monkeys

The TRIM family proteins share a conserved arrangement of three adjacent domains, an N-terminal RING domain, followed by one or two B-boxes and a coiled-coil, which constitutes the tripartite-motif for which the family is named. However, the C-termini of TRIM proteins vary, and include at least nine evolutionarily distinct, unrelated protein domains. Antiviral restriction factor TRIM5alpha has ...

Cyclophilin A is required for TRIM5 -mediated resistance to HIV-1 in Old World monkey cells

The peptidyl-prolyl isomerase cyclophilin A (CypA) embraces an exposed, proline-rich loop on HIV-1 capsid (CA) and renders reverse transcription complexes resistant to an antiviral activity in human cells. A CypA fusion with TRIM5 that is unique to New World owl monkeys also targets HIV-1 CA, but this interaction potently inhibits infection. A similar block to HIV-1 infection in Old World monke...

Old World Monkeys

Old World monkeys, or cercopithecoids, are a diverse and widespread group of primates found throughout Africa and Asia. They are characterised by their specialised molar teeth, quadrupedal running behaviour, often spending more time on the ground than other primates, as well as their often large and complex social groups. They survive inthewidest rangeofhabitatsofanynonhumanprimates, with some ...

Old World Monkeys

Evolution of New World Monkeys

RESEARCH ON the behavior and ecology of New World primates (infraorder Platyrrhini) began in the 1930s with C. R. Carpenter’s pioneering work on mantled howler monkeys (Alouatta paliatta) and Geoffroy’s spider monkeys (Ateles geoffroyi) in Panama (Strier 1994a, for a brief review). It was not until the late 1970s and 1980s, however, that signifi cant work on the ecology and behavior of wild pop...